Also, a study of both VDBP and VDR polymorphisms in CAD patients showed a strong association between the VDR (rs1544410, G > A) and VDBP (rs7041 T > G) genes polymorphisms and vitamin D deficiency [13], and the latter was also evaluated as a possible risk factor in CAD pathogenesis [14]. The gene discussed is VDR; the disease is vitamin D deficiency.