They showed that a single intravenous infusion of 2.5 × 1011 CD8-targeted lentiviral particles encoding a CD19-specific CAR (targeting B cells) substantially reduced the tumor burden in B cell lymphoma-bearing immunodeficient NOD scid gamma (NSG) mice that had been engrafted with human T cells prior to virus infusion (30). Here, CD8A is linked to neoplasm.