BRCA2 and neoplasm: Cluster 2 (n = 29) was enriched for copy-number deletions in well-known tumour suppressor genes (RB1, BRCA2, and PTEN), while cluster 3 (n = 121) contained numerous deletions affecting major PDAC gene loci (e.g. CDKN2A/B, TP53, and 9p24).