Abbreviations: AKI – acute kidney injury; ARDS – acute respiratory distress syndrome; BCR-ABL – Philadelphia chromosome; CPIs – checkpoint inhibitors; EGFR – epidermal growth factor receptor; HTN – hypertension; MMC- mitomycin C; PDGFr – platelet-derived growth factors receptor; PIs – proteasome inhibitors; PLD – pegylated lysosomal doxorubicin; TTP – thrombotic thrombocytopenic purpura; TKIs – tyrosine kinase receptors; VEGF – vascular endothelial growth factors; VEGFr – VEGF receptor. The gene discussed is GPLD1; the disease is acute kidney injury.