A comparable N-glycoproteome coverage was obtained for CSF samples collected from AD patients, but diverse and distinct glycosylation patterns were detected for glycoproteins such as alpha-1-antichymotrypsin, ephrin-A3 and carnosinase CN1 etc., which serve as promising glycosylation-based biomarker candidates for AD. The gene discussed is SERPINA3; the disease is Alzheimer disease.