CD4 and tuberculosis: Several rapid and cheap non-sputum-based diagnostic tests have shown promise at the point of care; in a prospective study of individuals initiating ART with CD4 cell counts less than 350 cells per μL, C-reactive protein testing had 89·0% sensitivity and 72·1% specificity, and significantly reduced the number of confirmatory Xpert MTB/RIF tests.4, 5 The Determine TB lipoarabinomannan (LAM) Ag assay had a sensitivity of only 31% among unselected outpatients with HIV in a Cochrane review.6