Consistently, when examined whether targets that had been identified by the fission yeast library could represent their effects in human breast cancer cells, ER+ MCF-7 cells transfected with siRNAs for five individual target genes (CSNK1G2, YWHAE, CDK1, HSPA1A, and CCT6A) and tested TAM-sensitive response. The gene discussed is CDK1; the disease is breast cancer.