Consistently, when examined whether targets that had been identified by the fission yeast library could represent their effects in human breast cancer cells, ER+ MCF-7 cells transfected with siRNAs for five individual target genes (CSNK1G2, YWHAE, CDK1, HSPA1A, and CCT6A) and tested TAM-sensitive response. This evidence concerns the gene CCT6A and breast cancer.