TP53 and cancer: On the other hand, analysis of cancers arising in LFS patients—with a germline mutation in one TP53 allele—showed loss of the WT allele in almost all cases with a p53-null mutation but in only around a third of tumors in LFS patients carrying a germline p53 mutation in the DBD (Varley et al. 1997; Varley 2003; Malkin 2011).