The impact of mutant p53 on the cancer cells secretome and consequent interactions between the tumor and stroma have been discussed in detail in several previous reviews (Cordani et al. 2016; Stein et al. 2019a; Blagih et al. 2020a; Pavlakis and Stiewe 2020; Pavlakis et al. 2020) and is briefly reviewed here. The gene discussed is TP53; the disease is cancer.