An analysis of genome-wide RNAi and CRISPR-Cas9 survival screens of cancer cell lines did not reveal the dependence of cancer cells on mutant p53 expression, although this study did show that many p53 point mutants acquire a DN ability to overcome WT p53 activation and allow proliferation and survival of cells in culture (Giacomelli et al. 2018). The gene discussed is TP53; the disease is cancer.