Furthermore, expression of mutant p53 enhances the reprogramming and transformation of somatic cells (Sarig et al. 2010) and drives abnormal self-renewal in acute myeloid leukemia beyond that seen following p53 loss, again supporting a role for mutant p53 beyond loss of WT function (Loizou et al. 2019). This evidence concerns the gene TP53 and acute myeloid leukemia.