CXCL12 and neoplasm: Examples include an ability of p53 in fibroblasts to exert a tumor-suppressive effect on the surrounding tissue by suppressing the expression of SDF-1/CXCL12, a chemokine that increases cell invasiveness (Moskovits et al. 2006) and the release of factors from p53-expressing hepatic stellate cells that promote macrophage polarization toward the tumor-suppressive M1 type (Lujambio et al. 2013).