Similarly, the ability of cancer cells to induce changes in macrophages was also shown to be dependent on the type of p53 mutation in the tumor cells, with R273H and R249S, but not p53 V157F and R175H, able to induce a tumor-promoting shift in the profile of M2 macrophages (Cooks et al. 2018). The gene discussed is TP53; the disease is cancer.