Changes in the proteins that are secreted by cancer cells can have a direct effect on their behaviors through autocrine or paracrine mechanisms, and the induced expression of a variety of p53 mutants including R175H, R248Q, R248W, R249S, R273H, and R282W in H1299 cells led to the expression of a proinvasive secretome that increased the invasiveness of cells with no p53 expression (Neilsen et al. 2011). Here, TP53 is linked to cancer.