Similarly, in mammalian systems, cells acquiring oncogenic alterations such as KRAS, SRC, or YES activation can be outcompeted by WT cells, while loss of tumor suppressor proteins SCRIBBLE or VPRBP confers loser status to cells when in competition with WT neighbors (Tanimura and Fujita 2020), consistent with a tumor-suppressive role of competition. This evidence concerns the gene KRAS and neoplasm.