The ability of mutant p53 to affect the structure of the ECM may have a feedback effect on the tumor cells, since mutant p53 is known to affect the trafficking of receptors that interact with the ECM, such as integrins (Muller et al. 2009), and become stabilized in response to changes in matrix stiffness (Ingallina et al. 2018). This evidence concerns the gene TP53 and neoplasm.