By crossbreeding Asah1fl/fl/Podocre mice with Smpd1−/− mice, we produced a double knockout strain, Smpd1−/−/Asah1fl/fl/Podocre, that also lacks Smpd1, the gene encoding ASM, to test whether reduction of ceramide production by ASM can reverse podocytopathy or NS induced by AC deficiency. This evidence concerns the gene SMPD1 and Farber lipogranulomatosis.