DNMT3A and aortic stenosis: In this cohort of patients with severe aortic stenosis, the presence of TET2 or DNMT3A was also associated with an elevated pro-inflammatory subset of circulating leucocytes and conferred a profound increased in mortality even after successful correction of the aortic valve stenosis (HR 3.1 [95% CI: 1.17–8.08]) [8].