UCHL1 and neurodegenerative disease: Glial fibrillary acidic protein and UCH-L1 have been approved as biomarkers for hemorrhagic TBI.19 Amyloid β peptides are crucial to neurodegenerative disease pathology.20 Glial fibrillary acidic protein, tau, and NfL have been used as objective measurements of adverse neurological outcomes.21,22,23 UCH-L1 and amyloid precursor protein have been identified in peripheral blood weeks to months after exposure to LLOP.24