Molecular testing on FNAC material has been employed in the diagnosis of thyroid nodules to better define the risk of malignancy and, in 2009, Nikiforov and co-workers demonstrated the feasibility of a molecular testing panel, including BRAF and RAS mutations as well as RET/PTC and PAX8/PPARγ rearrangements [15]. The gene discussed is PPARG; the disease is thyroid nodule.