Various FGFs are elevated in autoimmune diseases of the brain, such as multiple sclerosis: FGF1 in remyelinated lesions, FGF2 in active lesions and in the cerebrospinal fluid, FGF9 in active demyelinated lesions, and FGF21 in activated microglia or macrophages [151–153]. This evidence concerns the gene FGF9 and multiple sclerosis.