FGF signalling disturbances in mood disorders might be indirect, since the disruption of schizophrenia-associated proteins, such as the neuronal PAS domain protein 3 (NPAS3), correlates with a dramatic reduction in FGFR1 mRNA, and NPAS3 deficiency behaviourally resembles FGFR1 knock-out mice [199]. Here, NPAS3 is linked to schizophrenia.