This study highlights the need for not only frequent breast screening and, use of digital mammography but also screening for potential mechanism-based biomarkers (like Ubc9, SIRT-1, β-catenin, etc.)that can predict TNBC early in women with high mammography density and BRCA1 mutation thus reducing the mortality associated with these aggressive cancers leading to health equity. Here, SIRT1 is linked to cancer.