Importantly, improved formulation of tumor antigens, including neoantigens, with TLRa in self-assembling nanoparticles promoted improved uptake by and activation of APCs (eg, DCs) that was associated with enhanced immunogenicity and improved tumor clearance in 3 murine tumor models.121 They also found that peptide physical form is a key determinant of CD8+ T-cell immunogenicity. The gene discussed is CD8A; the disease is neoplasm.