Benitez-Ribas recently performed a phase I study of a DC vaccine pulsed with autologous tumor cell-lines lysate as the antigen administered intradermally with KLH as the adjuvant, which is used as a source of CD4+ T-cell (helper) epitopes to augment the response, in 9 patients with newly diagnosed diffuse midline glioma (DMG) (formerly termed “diffuse intrinsic pontine glioma” or “DIPG”), a highly aggressive and universally fatal subgroup of pediatric HGG.73 A specific antitumor response was observed in 8 patients as identified by immunologic studies in peripheral blood mononuclear cells. Here, CD4 is linked to diffuse intrinsic pontine glioma.