In accordance with the expected results, we observed a significant increase in the expression levels of pyroptosis-related markers in the liver of CD38-deficient septicemia mice, such as NLRP3 (Figures 5(a) and 5(b)), cleaved caspase-1 (Figures 5(a) and 5(d)), IL-1β (Figures 5(a) and 5(e)), and IL-18 (Figures 5(a) and 5(f)), accompanied by the increase in cleaved caspase-3 (Figures 5(a) and 5(g)). The gene discussed is IL18; the disease is Sepsis.