MAPK3 and Sepsis: The same as the current data, a report showed that the level of ERK1/2 phosphorylation in liver and lung tissue increased significantly compared to that in sham in polymicrobial sepsis; activated ERK1/2 can induce the activation of NF-κB and a series of proinflammatory cytokine gene expressions, leading to systemic inflammatory response and even multiple organ dysfunction in sepsis [57].