Of the 11 mouse Slfn members, Slfn1 and 8 inhibit T cell growth [5], Slfn2 and 3 inhibit proliferation and/or anchorage-independent growth of mouse malignant melanoma and renal cell carcinoma cells [11], and Slfn5 exhibits antineoplastic effects in mouse renal cell carcinoma cells. This evidence concerns the gene SLFN5 and melanoma.