And consistent with our results, Hetta et al. had demonstrated that the frequency of MDSCs was positively correlated with ALT, AFP, and HCV viral load and negatively correlated with CD8 T-cell frequency in subsets in Egyptian patients with hepatitis C virus-related hepatocellular carcinoma [35], not just the degree of liver fibrosis and inflammation. This evidence concerns the gene AFP and Hepatic fibrosis.