Differential expressions of Tspan7 in ischemic and non-ischemic muscles between C57BL/6 and BALB/c mouse strains, which display differential susceptibility to hindlimb ischemia and were used to identify the genes associated with vascular inflammatory responses to hindlimb ischemia, suggest a regulatory role of Tspan7 in peripheral arterial disease (17). This evidence concerns the gene TSPAN7 and peripheral arterial disease.