The macroalbuminuria and renal failure groups had higher prevalences of a history of hypertension, and higher IL-6 and IL-8 concentrations, but lower serum Zn, 24 h urine Zn loss, 24 h urine Mg loss, and eGFR than the normal and microalbuminuria groups (P < 0.05). The gene discussed is IL6; the disease is Hypertension.