Putting it all together it is clear that severe COVID 19 disease is associated with significantly increased leukocytes, neutrophils, infection biomarkers [such as CRP, PCT and ferritin] and cytokine levels [IL-2R, IL-6, IL-8, IL-10 and tumor necrosis factor (TNF)-α] and decreased lymphocyte counts (28). The gene discussed is TNF; the disease is infection.