Documented higher PT, D-Dimer, and fibrinogen values, with lower platelet count among severe patients. Twenty-five studies on 1511 COVID-19 non-survivors and 6287 survivors showed higher prothrombin time and D-Dimer values, with lower platelet count among non-survivors. Regression models showed that CRP values were directly correlated with the difference in prothrombin time and fibrinogen. Here, F2 is linked to COVID-19.