TNF and neoplasm: Similarly, both of CD4+ T cells and CD8+ T cells were activated in the CAER treatment group of 4T1 tumor-bearing BALB/c mice and CD8+ T cells responded dominantly (IFN-γ secreted CD8+ T cells increase to 6.32%, while CD4+ T cells to 1.61%; the secretion of TNF-α was increased to 9.28% in CD8+ T cells, while to 1.94% in CD4+ T cells) (Figures 5E, F).