In fact, in view of the inhibitory effect of a highly acidic environment on the immune system, researchers have been investigating ways to inhibit the tumor glycolysis pathway, such as targeting key enzymes of glycolysis [FX-11 (25) and oxamate (26)], lactic acid excretion [MCT-1/MCT-2 inhibitor like diclofenac (27)], and proton pump inhibitors [esomeprazole (28)], to combine them with immunotherapy. This evidence concerns the gene SLC16A7 and neoplasm.