PFN2 and cancer: In the top 20 KEGG pathways, we identified cancer-related pathways, including the TGF-β signaling pathway (involving SMAD5), the PI3K-Akt signaling pathway (involving IL7R), the Jak-STAT signaling pathway (involving IL7R), the MAPK signaling pathway (involving genes MAP2K6), the Rap1 signaling pathway (involving MAP2K6 and PFN2), and cell adhesion molecules (involving PTPRC) (Table 2).