In the top 20 KEGG pathways, we identified cancer-related pathways, including the TGF-β signaling pathway (involving SMAD5), the PI3K-Akt signaling pathway (involving IL7R), the Jak-STAT signaling pathway (involving IL7R), the MAPK signaling pathway (involving genes MAP2K6), the Rap1 signaling pathway (involving MAP2K6 and PFN2), and cell adhesion molecules (involving PTPRC) (Table 2). This evidence concerns the gene SMAD5 and cancer.