Among them, we mainly analyzed four genes (EGFR and BMP1 in ESCC and IL-1B and MAPT in EAC) that were related to gender, tumor stage, lymph node metastasis, distant metastasis, and other clinical features in EC, supposing that they might play essential roles in the prognosis of EC patients. The gene discussed is EGFR; the disease is esophageal squamous cell carcinoma.