CCN3 and neoplasm: Chromogranin B (CHGB), oxytocin receptor (OXTR), and cellular communication network factor 3 (CCN3) also belong to cytokine and cytokine receptor, which play a vital role in the homeostasis of innate and adaptive immunity and remarkably affect anti-tumor immunity through activating cytotoxic T cells and cancer immunotherapy (48, 49).