We examined the levels of three autophagy-related proteins, MAP1LC3B (LC3B), p62, and LAMP2A, by IHC in the normal-to-carcinoma spectrum, and we describe their heterogeneous expression patterns in our cohort of gastric/GEJ adenocarcinoma. The gene discussed is SQSTM1; the disease is gastroesophageal junction adenocarcinoma.