HIF1A and neoplasm: Natarajan et al. showed enhanced expression of proline-lysine hydroxylases and lysyl oxidase in mesothelial cells leading to increased collagen deposition and increased collagen cross-linking respectively in the hypoxic tumor microenvironment, and this collagen remodeling subsequently leads to tumor invasion as hypoxia-inducible factor-1 and factor-2 (HIF-1 and 2) gets stabilized [4].