The most significant pathways in the KEGG database for the down-regulated gene set (Fig. 2B), were: PI3K-Akt signaling pathway (number of genes: six), pathways in cancer (six), Neuroactive ligand–receptor interaction (four), and estrogen signaling pathway (three), in a total of 4 pathways and 10 non-redundant genes. Here, AKT1 is linked to cancer.