In accordance with the previous research reporting that inhibition of GATA6/VCAM-1 contributed to the anti-atherosclerotic effect of RARα/RXRα agonists in Apoe-/- mice 38, the current study revealed that a similar mechanism is shared by both human and mouse arterial EC that also accounts for the beneficial effect of Romidepsin on the suppression of atherosclerosis. The gene discussed is APOE; the disease is atherosclerosis.