RSPO1 and Hepatic fibrosis: A recent study showed that the application of Rspo1, a molecule that promotes lgr5+ liver stem cells in vitro, along with VPA and EPZ6438, was indispensable for the culture of hyperplastic intestinal organoids and could significantly inhibit liver fibrosis and promote regenerative responses in the intestinal epithelium after irradiation in vivo9, 21.