By overexpressing human P301L mutant tau, the human tau with the most common FTDP-17 mutation 45, we found that P301L mutant tau overexpression inhibited STAT3 translocation into the nucleus and inactivated STAT3 by increasing the interaction of acetylated STAT1 with STAT3 in the cytoplasm 25. The gene discussed is STAT3; the disease is semantic dementia.