Like STAT1, STAT3 binds to a similar GAS element of target genes and also involved in cognition regulation 8, 9, and phospho-STAT3 level in hippocampal neurons age-dependently decreased in both AD model mice and AD patients 20, we speculate that STAT3 may also play a key role in the hTau-induced cognitive deficits. This evidence concerns the gene STAT1 and Alzheimer disease.