Considering the importance of the TH1-type chemokines CXCL9 and CXCL10 to T-cell recruitment, certain tumors show low levels of CXCL9 and CXCL10 expression, which may explain the reduced infiltration of effector T lymphocytes into these tumor beds 32, 36. Here, CXCL9 is linked to neoplasm.