Local administration of the TLR7/8 agonist imidazoquinoline with coupled nanoparticles significantly activated the DCs of secondary lymphoid organs, upregulated the expression of MHC-II, CD40, and CD86 on their surface, and expanded the number of tumor-specific CD8+ T lymphocytes, which inhibited tumor growth 101. The gene discussed is CD8A; the disease is neoplasm.