Moreover, all of the eight novel hypermethylation driver genes (PCDH17, IRX1, ITGA5, HSPB6, TBX5, ADCY8, GALNT13 and TCTEX1D1) were successfully validated in an independent cohort via a pyrosequencing approach, with an AUC of 0.965 for prediction of lung cancer patients. Here, HSPB6 is linked to lung cancer.