Then, we measured the effect of C004019 on tau clearance in different cell models, including HEK293-hTau cells (with stable hTau expression), HEK293 cells with transient expression of human tau (HEK293-3xFlag-hTau or HEK293-EGFP-hTau), and the human neuroblastoma SH-SY5Y cells which constitutively express human tau proteins. This evidence concerns the gene MAPT and neuroblastoma.