It had been proved that the shift from oxidative phosphorylation to glycolysis was due to the activation of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) in the hyperproliferation of PASMCs in PAH 41. The gene discussed is PFKFB3; the disease is pulmonary arterial hypertension.