We found that CBD treatment significantly reduced the mRNA levels of DRP1, FIS1, OPA1, whereas the expressions of DRP1, FIS1, OPA1 were upregulated in hypoxia-induced human PASMCs (Figure S6D-F), and CBD could also decrease the protein expressions of DRP1 and FIS1 in the mice PAH-PASMCs (Figure 4D). The gene discussed is OPA1; the disease is pulmonary arterial hypertension.