Conversely, CBD upregulated the mRNA of MFN1, MFN2, and MIEF1 in hypoxia-induced human PASMCs (Figure S6G-I) and protein expression of MFN2 in mice PAH-PASMCs (Figure 4D), compared with the group without CBD treatment, respectively. This evidence concerns the gene MIEF1 and pulmonary arterial hypertension.