PFKFB3 and pulmonary arterial hypertension: We observed that CBD could reduce the elevated mRNA level of Pfkfb3 in the lungs of hypoxia-induced PAH mice and mice PAH-PASMCs (Figure 6F, Figure S8H), PFKFB3 protein expression pattern was similar in both lungs of PAH mice and in vitro PASMCs (Figure 6G).