NFE2L2 and cancer: However, recent evidence has revealed that aberrant activation of NRF2 is associated with cancer hallmarks 4-10, including promoted tumorigenesis 11, 12, sustained proliferative signaling and survival advantage 7, 13, 14, resistance to treatment 15-18, deregulated redox homeostasis 19-21, enhanced tissue invasion and metastasis 14, 22, 23, and altered cellular metabolism 13, 24-26.