NFE2L2 and neoplasm: The hematoxylin and eosin (H&E) and IHC staining of lung tissue sections demonstrated that mice bearing NRF2-knockdown Ca9-22-D1 cells significantly inhibited lung-specific metastatic tumor foci formation compared with mice bearing mock control cells, and NRF2 expression level is positively correlated with the number of tumor foci (Figure 3H).