Similar to clinical findings, the expression of NRF2 protein was markedly higher in the HNSCC cell lines than in dysplasia oral keratinocytes (DOK; Figure 1E), and lower levels of NRF2 protein were observed in normal human oral keratinocytes (NHOK) compared to DOK and HNSCC cells (Figure S3). The gene discussed is NFE2L2; the disease is dysplasia.