Although treatment of cells with N-acetyl cysteine (NAC), a widely used pharmacological antioxidant, effectively reduced ROS production (Figure 4D, Figure S12B), addition of NAC did not restore cell growth (Figure 4E, Figure S12C) and migration ability (Figure 4F, Figure S12D) in NRF2-knockdown HNSCC cells. Here, NFE2L2 is linked to head and neck squamous cell carcinoma.