In addition to PPP and glycolysis, the ten most highly enriched down-regulated metabolism pathways in NRF2 knockdown HNSCC cells also included amino acid, nucleotide, xenobiotics, heme, and fatty acid metabolism as well as oxidative phosphorylation (Figure S13B), and many of them have been known to modulate head and neck oncogenesis 78. Here, NFE2L2 is linked to head and neck squamous cell carcinoma.