Four heat shock proteins (Hspa5, Hsp90ab1, Hspa8 and Hsp90aa1) were included in the top candidate list and Hsp90ab1 was predicted to be one of the most influential tumor suppressors, as well as calreticulin (Calr) and peptidylprolyl isomerase B (Ppib). The gene discussed is HSP90AA1; the disease is neoplasm.