In this study, we utilize STIM1 score as a surrogate of STIM1 expression in order to gain four advantages: 1) reduction in false negatives; 2) addition of information regarding STIM1-mediated cellular programs, which may not be reflected by STIM1 expression alone (Supplementary Figure S12); 3) production of superior scoring in human melanoma tissues when compared to cell lines 17; and 4) delineation of malignant STIM1 expression in bulky melanoma data by diminishing confounding effects from non-malignant cell types 5 (Figures 1C and E). The gene discussed is STIM1; the disease is melanoma.