IL16 and melanoma: By leveraging two additional melanoma cell line (i.e. malignant cell) expression datasets (GSE7929 [n = 11] and GSE1845 [n = 5]), the positive correlation (i.e., Pearson's product-moment correlation coefficient > 0) of STIM1 to 3 (of 9) ligands was successfully validated including CXCL12, IL16 and CCL5 (Supplementary Figure S15).