The mechanisms of inhibition were via suppression of osteoporosis-related protein expression (NFATc1 and c-Fos), gene expression (Nfatc1, Ca2, Acp5, mmp9, CtsK, Oscar, and Atp6v0d2), and inhibited bone loss induced in the OVX model. The gene discussed is NFATC1; the disease is osteoporosis.