Conversely, Fan et al. (2020) found that the histone demethylase KDM3A (JMJD1A) positively regulates the expression of DDR genes by promoting both the expression of c-Myc and its chromatin recruitment through H3K9 demethylation, suggesting a new possible target to sensitize prostate cancer to radiotherapy (Fan et al., 2020). The gene discussed is KDM3A; the disease is prostate cancer.