CD8A and steatosis: These results were also observed in the liver: more than 95 and 85% of CD4+ and CD8+ T cells, respectively, expressed the effector memory T cell phenotype in non-SPF mice on HFD, which was accompanied by severe steatosis, lobular inflammation, hepatocellular ballooning and destroyed lobule structure while only some SPF mice displayed a mild fat accumulation in the liver (137).