For instance the CARD11 scaffold protein showed increasing levels from naive B-cells (lacking CARD11 expression) to memory B-cells, this protein being altered in a spectrum of diffuse large B-cell lymphomas (DLBCL) (51), mainly those derived from GC (GCB-DLBCL) and activated B-cells (ABC-DLBCL) (52), where it plays a key role in activating the NF-kB pathway to induce the B-cell proliferation and the proliferation vs death checkpoint in activated B-cells (52). This evidence concerns the gene CARD11 and diffuse large B-cell lymphoma.