Conversely, uptake of human apoptotic neutrophils by DCs has also been shown to impair DC co-stimulation and antigen presentation, resulting in diminished allogeneic T cell responses (51). Apoptotic PMN that have taken up tumor cell-released autophagosomes display enhanced immunosuppressive functions: they inhibit the proliferation and activation of both CD4+ and CD8+ T cells in a process requiring cell-contact and the generation of ROS (52). The gene discussed is CD4; the disease is neoplasm.