For example, lactoferrin promotes Th1 generation in concert with BCG vaccination (44) and increases T cell cytokine production during infection with Staphylococcus aureus (45); the neutrophil alpha defensins induce NFkb signalling in T cells (46); and the granule peptide cathelicidin promotes Th17 differentiation (21) and activates CD8+ T cells (47). Here, CD8A is linked to infection.