In individuals with CF, the CFTR protein is not expressed in the muscles (Divangahi et al., 2009), leading to cellular alterations that include the oxidative metabolism (Antigny et al., 2009), and reduction of contractile excitability (Clay, 2013), translating into exercise intolerance and decreased muscle strength (Gruet et al., 2017), which contributes to a decreased level of activities, causing a worst response of the ANS. Here, CFTR is linked to cystic fibrosis.