We found that EAT may participate in CAD through key genes including GNG3, MCHR1, BDKRB1, MCHR2, CXCL8, CXCR5, CCR8, CCL4L1, TAS2R10, and TAS2R41, and some novel pathways, including cytokine-cytokine receptor interaction, jak-STAT signaling pathway, nicotine addiction, chemokine signaling pathway, hematopoietic cell lineage, steroid hormone biosynthesis, butanoate metabolism, and neuroactive ligand-receptor interaction. Here, CXCL8 is linked to nicotine dependence.