Hussein et al. reported that treatment of DKD rats with the Sirt1 agonist resveratrol increased superoxide dismutase (SOD) activity and reduced malondialdehyde (MDA), collagen (Col) IV, and fibronectin (FN) expression by increasing FoxO1 activity (Hussein and Mahfouz, 2016). The gene discussed is SIRT1; the disease is diabetic kidney disease.