FOXO1 and type 1 diabetes mellitus: The transcriptional activity of FoxO1 decreased in the kidney from type 1 diabetic rodents induced by streptozotocin (STZ) and the podocytes cultured under high-glucose (HG) condition (Guo et al., 2015; Du et al., 2016; Li et al., 2016; Li et al., 2017).