Hussein et al. reported that treatment of DKD rats with the Sirt1 agonist resveratrol increased superoxide dismutase (SOD) activity and reduced malondialdehyde (MDA), collagen (Col) IV, and fibronectin (FN) expression by increasing FoxO1 activity (Hussein and Mahfouz, 2016). This evidence concerns the gene FN1 and diabetic kidney disease.