MBD3 and brain cancer: In brain cancer, critical gene networks involving Olig2 have been shown to be related to epigenetic regulation such as methyl CpG-binding domain protein 3 (MBD3), a transcriptional repressor and gene silencer for methylated CpG dinucleotide containing sites, and histone deacetylase 7 (HDAC7), an epigenetic repressor responsible for transcriptional regulation, cell cycle progression, and development (Tsigelny et al., 2016).