From that standpoint, it is intriguing to observe that MS patients who lacked CELs still had elevated CSF levels of CEL-associated biomarkers: IL-12p40 (1.3-fold), CHI3L1 (5.6-fold), TNFα (1.6-fold), and IL10 (2.0-fold) in comparison to HD medians. The gene discussed is CHI3L1; the disease is myeloid sarcoma.