In a correlation matrix a strong cluster of four proinflammatory biomarkers (CHI3L1, IL-12p40, TNFα, and TNFβ) can be identified; these four proinflammatory biomarkers were significantly elevated in active MS patients, and they were strongly correlated with axonal damage (cNfL) and number of CELs. This evidence concerns the gene TNF and myeloid sarcoma.