In a correlation matrix a strong cluster of four proinflammatory biomarkers (CHI3L1, IL-12p40, TNFα, and TNFβ) can be identified; these four proinflammatory biomarkers were significantly elevated in active MS patients, and they were strongly correlated with axonal damage (cNfL) and number of CELs. The gene discussed is CHI3L1; the disease is myeloid sarcoma.