Surprisingly, we found that other inflammatory CSF markers, especially those associated with adaptive immunity are elevated in both MS subgroups (i.e., with CELs or without) comparatively: CD27 (mostly secreted by T cells, CD8 > CD4), CD21 (secreted by naïve B cells), BCMA (secreted by plasma cells), and CXCL13 (chemokine secreted by follicular helper T cells and follicular dendritic cells that is B cell attractant). Here, CD4 is linked to myeloid sarcoma.