Interestingly, we found that the expression of NFATc1 and DDIAS was elevated in H23 and H1703 cells, as well as in four gefitinib-resistant PDCs, but was downregulated in gefitinib-sensitive lung cancer cells, such as H358 and Calu-3 cells (Figs. 3a; 6a, c; and Supplementary Fig. 4). This evidence concerns the gene NFATC1 and lung cancer.