WNT2 and non-small cell lung carcinoma: Even though the lead compound has the same core skeleton of as previous research targets, the lead compound with the most potent targeted activity toward DDIAS transcription, DGG-100629, has a building block chemical structure (2-ethoxy ethyl amine group) quite different from that of the previous targets in NSCLC or the Wnt2/β-catenin pathway (2-ethoxy amine group).