In addition, 2,3,6-trisubstituted quinoxaline derivatives and 3-arylethynyl-substituted thieno[3,4-b]-pyrazine derivatives were identified as Wnt2/β-catenin pathway inhibitors and transglutaminase 2 inhibitors in NSCLC and renal cancer cells, respectively17,18. This evidence concerns the gene WNT2 and non-small cell lung carcinoma.